巨噬清除

PBS Liposomes（Blank）

PBS Liposomes（Blank )空脂質體，作為Clodronate Liposomes的嚴格對照，通過與Clodronate Liposomes相同的機制被單核細胞/巨噬細胞識別和吞噬。由于對照脂質體不含氯膦酸鹽，因此單核細胞/巨噬細胞不會被清除。然而，單核細胞/巨噬細胞確實/可能通過細胞因子分泌、吞噬活性的暫時中止和文獻中描述的其他反應來對因PBS Liposomes對照脂質體的攝入產生反應。

PBS Liposomes(Blank) are formulated and prepared identically to Clodronate Liposomes except that clodronate is not added to the liposomes. PBS Liposomes(Blank) are recognized and phagocytosed by the same mechanism as Clodronate Liposomes.However, phagocytes do respond to the ingestion of control liposomes by cytokine secretion, temporary suspension of phagocytic activity and other responses described in the literature.

Highlights:

* Reduce the background values of the experimental and control groups

* The most ideal and rigorous control relative to PBS, etc

貨號 品名 規格 庫存 價格
CLD-8910-2ml
 PBS Liposomes(Blank) 2ml in stock 1500.0
CLD-8910-5ml
 PBS Liposomes(Blank) 5ml in stock 2900.0
CLD-8910-10ml
 PBS Liposomes(Blank) 10ml in stock 5500.0
CLD-8910-15ml
 PBS Liposomes(Blank) 15ml in stock 7500.0
CLD-8910-20ml
 PBS Liposomes(Blank) 20ml in stock 10000.0
CLD-8910-25ml
 PBS Liposomes(Blank) 25ml in stock 13000.0
產品詳情

品類型/Product Type:Chemicals
產品名稱/Name:PBS Liposomes(Blank)
脂質構成/Lipid Composition:Cholesterol, L-alpha-Phosphatidylcholine
包裹藥物/Encapsulated Drug:None
外觀形態/Format:White milky suspensions
緩沖液/Buffer: Phosphate buffered saline (20 mM sodium phosphate, 0.9 % NaCl)
PH值/PH: 7.0-7.5
保存期/Shelf Life3 months guaranteed for unopened vials at 2-8 oC
注意事項/Comments: Liposomes should be kept at 2-8°C and NEVER be frozen
存儲溫度/Storage: Upon receipt store at 2-8℃
運輸溫度/Shipped:Ice pack  

產品源頭

Country of origin: USA

參考文獻

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  34. Van Lent PL, Van den Hoek AE, Van den Bersselaar LA, Spanjaards MF, Van Rooijen N, Dijkstra CD, Van de Putte LB, Van den Berg WB. In vivo role of phagocytic synovial lining cells in onset of experimental arthritis. Am J Pathol. 1993 Oct;143(4):1226-37. PMID: 8214013; PMCID: PMC1887048. View article

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  52. Nair S, Buiting AM, Rouse RJ, Van Rooijen N, Huang L, Rouse BT. Role of macrophages and dendritic cells in primary cytotoxic T lymphocyte responses. Int Immunol. 1995 Apr;7(4):679-88. doi: 10.1093/intimm/7.4.679. PMID: 7547695. View article 

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  54. Huitinga I, Ruuls SR, Jung S, Van Rooijen N, Hartung HP, Dijkstra CD. Macrophages in T cell line-mediated, demyelinating, and chronic relapsing experimental autoimmune encephalomyelitis in Lewis rats. Clin Exp Immunol. 1995 May;100(2):344-51. doi: 10.1111/j.1365-2249.1995.tb03675.x. PMID: 7743675; PMCID: PMC1534326. View article

  55. Gaytan F, Bellido C, Morales C, Reymundo C, Aguilar E, van Rooijen N. Response to Leydig cell apoptosis in the absence of testicular macrophages. J Reprod Immunol. 1995 May;29(1):81-94. doi: 10.1016/0165-0378(95)00934-d. PMID: 8531194. View article

  56. Vanderkerken K, Bouwens L, Van Rooijen N, Van den Berg K, Baekeland M, Wisse E. The role of Kupffer cells in the differentiation process of hepatic natural killer cells. Hepatology. 1995 Jul;22(1):283-90. PMID: 7601422. View article

  57. Fraser CC, Chen BP, Webb S, van Rooijen N, Kraal G. Circulation of human hematopoietic cells in severe combined immunodeficient mice after Cl2MDP-liposome-mediated macrophage depletion. Blood. 1995 Jul 1;86(1):183-92. PMID: 7795223. View article

  58. Salkowski CA, Neta R, Wynn TA, Strassmann G, van Rooijen N, Vogel SN. Effect of liposome-mediated macrophage depletion on LPS-induced cytokine gene expression and radioprotection. J Immunol. 1995 Sep 15;155(6):3168-79. PMID: 7673730. View article

  59. Bayón LG, Izquierdo MA, Sirovich I, van Rooijen N, Beelen RH, Meijer S. Role of Kupffer cells in arresting circulating tumor cells and controlling metastatic growth in the liver. Hepatology. 1996 May;23(5):1224-31. doi: 10.1002/hep.510230542. PMID: 8621157. View article

  60. Van Rooijen N, Sanders A. Kupffer cell depletion by liposome-delivered drugs: comparative activity of intracellular clodronate, propamidine, and ethylenediaminetetraacetic acid. Hepatology. 1996 May;23(5):1239-43. doi: 10.1053/jhep.1996.v23.pm0008621159. PMID: 8621159. View article

  61. Buiting AM, Zhou F, Bakker JA, van Rooijen N, Huang L. Biodistribution of clodronate and liposomes used in the liposome mediated macrophage 'suicide' approach. J Immunol Methods. 1996 Jun 10;192(1-2):55-62. doi: 10.1016/0022-1759(96)00034-8. PMID: 8699022. View article

  62. van Rooijen N, Sanders A, van den Berg TK. Apoptosis of macrophages induced by liposome-mediated intracellular delivery of clodronate and propamidine. J Immunol Methods. 1996 Jun 14;193(1):93-9. doi: 10.1016/0022-1759(96)00056-7. PMID: 8690935. View article

  63. Gaytan F, Bellido C, Morales C, García M, van Rooijen N, Aguilar E. In vivo manipulation (depletion versus activation) of testicular macrophages: central and local effects. J Endocrinol. 1996 Jul;150(1):57-65. doi: 10.1677/joe.0.1500057. PMID: 8708563. View article

  64. Karupiah G, Buller RM, Van Rooijen N, Duarte CJ, Chen J. Different roles for CD4+ and CD8+ T lymphocytes and macrophage subsets in the control of a generalized virus infection. J Virol. 1996 Dec;70(12):8301-9. doi: 10.1128/JVI.70.12.8301-8309.1996. PMID: 8970949; PMCID: PMC190917. View article

  65. de Haan A, Groen G, Prop J, van Rooijen N, Wilschut J. Mucosal immunoadjuvant activity of liposomes: role of alveolar macrophages. Immunology. 1996 Dec;89(4):488-93. doi: 10.1046/j.1365-2567.1996.d01-787.x. PMID: 9014811; PMCID: PMC1456575. View article

  66. Wolff G, Worgall S, van Rooijen N, Song WR, Harvey BG, Crystal RG. Enhancement of in vivo adenovirus-mediated gene transfer and expression by prior depletion of tissue macrophages in the target organ. J Virol. 1997 Jan;71(1):624-9. doi: 10.1128/JVI.71.1.624-629.1997. PMID: 8985392; PMCID: PMC191093.. View article

  67. van Rooijen N, Sanders A. Elimination, blocking, and activation of macrophages: three of a kind? J Leukoc Biol. 1997 Dec;62(6):702-9. doi: 10.1002/jlb.62.6.702. PMID: 9400810. View article